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It is important to know that for people who just start using this stuff, Oxymetholone is going to prove itself as an extremely potent anabolic steroid hormone as the newbies are able to see huge gains of as much as 30 lbs or maybe even more.
What is Oxymetholone?
What is Anadrol? What Does Anadrol Do?
Although this product can make you have huge gains - still, it is important to know that how much as you eating is going to play the essential role here as you can’t grow by not eating enough. It is pretty important to mention that Dihydrotestosterone and mestanolone are both some very weak products in that regard, owing to the fact that those molecules are not very stable in the high enzyme (3 alpha hydroxysteroid dehydrogenase) environment of the muscle tissue. Instead, the Oxymetholone steroid is remaining very highly active here as it is being reported in the standard animal assay tests that is demonstrating a very significantly higher anabolic activity than testosterone or methyltestosterone.
These assays mentioned earlier of this ingredient, are proving that the androgenicity of the Oxymetholone steroid is also pretty low (1/4th to 1/7th its anabolic activity), even though the real world results in the human use is suggesting that it is in fact much higher than that. It was mentioned that Oxymetholone is one of the most powerful steroids out there but in fact, by many people, this steroid is considered the be the absolute most powerful steroid that is commercially available.
All of this thanks to its really powerful effects – as it was said earlier, a person who is newbie to Oxymetholone is likely to gain around 20 to 30 pounds of massive bulk and very often, this gain is being made in the period of 6 weeks of use. It is important to understand that a lot of this weight isn’t going to be pure muscles as the steroid is producing a lot of water retention, that’s why a good amount from that gain would be water weight. But still, that’s very rarely a problem for the user as most of them are still feeling very big and extremely strong while using Oxymetholone which is still holding true.
Since users of Oxymetholone might get a pretty big amount of water retention they might get a smooth look and even though very often this look is not as attractive, it is still very often pretty helpful to the users are it can help with the size and strength gained. The muscle is fuller, is going to contract better and is also going to offer some level of protection in the form of extra water that is being held into and around the connective tissues. That’s really good for the bodybuilders and athletes as it is going to allow for more elasticity and therefore, this is hopefully going to greatly decrease the chances for the injury when the user is lifting some heavy weight.
Nonetheless, it still must be noted the fact that a very rapid gain in the muscle mass might also place way too much stress on the connective tissues either. The tearing of the pectoral and biceps tissue it is very commonly being associated with some heavy lifting in the time that massing up on the steroids and Oxymetholone is a very common offender. In case some of you didn’t know it – there are such things in the bodybuilding as gaining too fast and very often, steroids like Oxymetholone are involved in there. The chemical names of this product include: 17 beta-hydroxy-2-hydroxymethylene-17 alpha-methyl-5 alpha-androstan-3-one with an active life in the body of less than 16 hours while detection time is up to 8 weeks.
Oxymetholone Estrogenic Side Effects
Oxymetholone (Anadrol) is a very highly estrogenic steroid and this is the main reason why it is very possible to get the high estrogen related side effects. Like for example, gynecomastia is very often a concern during the administration with Oxymetholone and proper measures should be taken if you want to avoid this side effect.
This particular side effect may be noticed pretty early into a cycle and that’s especially true when some higher doses are being used. In addition to that, other high estrogen related side effects can be noticed in the same time – for example water retention can become a problem because generally this side effect is avoided because is causing a pretty noticeable loss of the muscle definition as both the subcutaneous water retention and fat levels build. In order to be able to avoid getting the strong estrogenic side effects, it may be required to use an anti estrogen like for example Nolvadex and Arimidex as in most cases the use of an anti estrogen is imperative. Likewise, they would not affect the relative estrogenic activity of this hormonal steroid.
There are some people who have suggested that the high level of estrogenic activity in oxymetholone is actually done because of the drug that is acting as a progestin, which is pretty similar to the nandrolone steroid. Remember that the side effects of both the high estrogen or high progestin amounts can be very similar, which might have made this explanation a plausible one. The fact that proves is that there are some steroids which are not offering estrogenic activity, but they are offering only high progestin amounts and people administering those steroids still get estrogen related side effects.
There has been a medical study where was examining the progestational activity of Oxymetholone and it has proven the fact that there was no such activity present in there. This is the main reason why it is thought that the high estrogen related side effects are occurring exclusively only because of the fact that this steroid is being aromatized to estrogen. With such things being found out, it does looks most plausible that Oxymetholone can active the estrogen receptor, pretty similar to, however much more pronounced than, the estrogenic androgen called methandriol.
Oxymetholone Androgenic Side Effects
Although Oxymetholone is classified as an anabolic steroid, is still having some extremely potent androgenic activity and with this being said, the androgenic side effects are very possible when administering this anabolic steroid. Therefore, androgen related side effects such as oily skin, acne, body hair growth as well as hair loss in those men who are genetically predisposed to it are all very possible, and that’s especially true in those men who are genetically predisposed to them.. These are the side effects that are offered by nearly all anabolic steroids as they are all offering androgenic activity, however Oxymetholone is considered to offer more androgenic activity compared to many other steroids.
In addition to that, it is important to know that the androgenic side effects of Oxymetholone can also include virilization in women and with this being said, such side effects as body hair growth, clitoral enlargement, menstrual irregularities, a deepening of the vocal chords as well as changes in skin texture are all possible. In fact, they are ensured in case a woman would take too high doses of it because there are a lot of situations in which women were induced virilizing symptoms even with reasonable doses. So it is important to remember that is still possible and it may occur even in low doses, this is the main reason why Oxymetholone, generally, is not a recommended compound for women’s use for performance and physique enhancing purposes. There are other steroids that are considered much safe.
In case the virilization symptoms is going to occur and Oxymetholone is being discontinued, the symptoms are going to fade away very soon, however in case those symptoms are going to be ignored and the use of the steroid continued, then there’s quite a high chance that the symptoms are going to become irreversible and would be permanent. But the main reason why women shouldn’t use Oxymetholone is because virilizing symptoms are thought to appear as soon as they start using it so they must discontinue with it.
One interesting thing to note here is the fact that Oxymetholone does show some tendency to convert itself to dihydrotestosterone in the body, even though this does not seem to occur via the 5 alpha reductase enzyme. Oxymetholone is already a dihydrotestosterone based steroid and that’s why no such alteration can take place. Besides from the added C17 alpha alkylated (that is being discussed below in this article), the Oxymetholone steroid is differing from DHT only by the addition of the 2 hydroxymethylene group as it was already mentioned in the beginning here. This is important as this grouping can be removed metabolically, reducing Oxymetholone to the potent androgen 17alpha methyl dihydrotestosterone (mestanolone).
There is very little doubt left that this biotransformation is contributing at least on some level to the androgenic nature of this steroid. It is quite important to note here that since 5 alpha reductase is not being involved here, the relative androgenicity of the steroid is not going to be affected by the concurrent use of 5 alpha reductase inhibitors like for example dutasteride or finasteride as it can happen with other steroids.
Oxymetholone Hepatotoxicity Side Effects
Oxymetholone is an oral steroid so is a C17 alpha alkylated substance. This alteration is protecting the drug from deactivation by the liver, therefore is allowing a very high percentage of the drug to enter into the bloodstream after the oral administration of the drug. Absolutely all of the C17 alpha alkylated anabolic/ androgenic steroids can be hepatotoxic so liver issue might become a problem. This is the reason why prolonged or high exposure (high doses) are not recommended because they may result in liver damage. In fact, by having too high exposures or way too much prolonged exposure to the C17 alpha alkylated substances, there are some rare instances where life threatening dysfunction might occur.
With all of this being said, it is highly recommended to periodically visit a physician during the cycle of C17 alpha alkylated products in order to check the liver function and the overall health. The intake of the C17-alpha alkylated steroids are commonly limited as they should not go further than 6 to 8 weeks, although Oxymetholone is so hepatotoxic that 8 weeks might be too much and 4 weeks is what most people should go for. This is done in the attempt to avoid escalating liver strain and keeping it healthy without damaging the liver. This is one of the main reasons why those people who are already having some/ any liver issues shouldn’t use C17 alpha alkylated compound /steroids. Oxymetholone is not being recommended to such people.
Oxymetholone is having a saturated A ring, and this is slightly reducing its relative hepatotoxicity. Nonetheless, it is still very important to keep in mind that this steroid, especially at the doses that are commonly used, can still offer substantial hepatotoxic effects to the person using it.
There are studies involving Oxymetholone use where participants were using 50 mg and 100 mg daily to 31 elderly men for 12 weeks. The study proven that it offered pretty significant increases in liver enzymes (transaminases AST and ALT) only in the patients that were using 100 mg as they didn’t really got big chances for the patients using 50 mg. There was also a second study done where people were using 50 mg daily to 30 patients for around one year and there were even some patients that took it for longer than that which has proved there are increases in the yglutamyltransferase (GGT) in 17% of patients, pretty significant increases in the bilirubin of 10%, andserum albumin increased in 20%.389. There’s also a patient which has developed a liver tumor that could have been peliosis hepatitis, that’s a life threatening adverse even that is being characterized by blood filled cysts in the liver. There’s also a small number of some other cases of peliosis hepatitis which have been linked to the Oxymetholone use and this is proving the potential for the hepatotoxicity as it should be very carefully considered before using this steroid.
During the administration with the Oxymetholone, is strongly recommended to follow a few steps. First of all – never use Oxymetholone with another C17 alpha alkylated steroid as this would stress the liver even more. Also – never use Oxymetholone or any other C17 alpha alkylated anabolic steroid with excess alcohol, but it is better and strongly recommended to avoid any alcohol consumption at all. General consensus of using Oxymetholone is for physique and/ or performance enhancing purposes. It is very well known that alcohol is the enemy of such purposes because alcohol is working as an anti performance and physique enhancer. There’s just no point in taking one while using another.
Plus to that, is strongly recommended any OTC medications during the administration with Oxymetholone. If that’s possible, do not use any OTC medications unless it is an absolute need. As mentioned – many OTC drugs are even more hepatic than Oxymetholone which is already considered a very hepatotoxic steroid compared to others. Plus to that, the use of a liver detoxification supplement like for example Liver Stabil, Essential Forte or Liv 52 is recommended during the administration with the steroid, not only Oxymetholone but any other anabolic/ androgenic steroids that are offering hepatotoxic activity and liver stress.
Oxymetholone Cardiovascular Side Effects
Remember that all of the anabolic/ androgenic steroids can have deleterious effects on the serum cholesterol. The effects are including a tendency to reduce the HDL (good) cholesterol numbers and in the same time to increase the LDL (bad) cholesterol numbers and this may shift the HDL to LDL balance into a direction that is favoring a greater risk of arteriosclerosis. The impact of the steroid is depending on a few different things. For example, the impact of the steroids on the serum lipids depends on the route of administration (oral or injectable), it is very highly dependent on the dosage, on the type of steroid (either aromatizable or non aromatizable) as well as on the level of the resistance to the hepatic metabolism.
Oxymetholone is having a pretty strong effect on the hepatic management of the cholesterol because of its structural resistance to liver breakdown, to its non aromatizable nature and to its oral route of administration. With all of these combined together, we can understand that Oxymetholone is by far not the mildest steroid to the cardiovascular side effects. The anabolic/ androgenic steroids also may have a negative effect on the blood pressure and on the triglycerides, it may reduce the endothelial relaxation and to support the left ventricular hypertrophy, all of which can potentially elevate the risk of the cardiovascular disease as well as the myocardial infarction.
As said, Oxymetholone has a strong effect on the hepatic management of cholesterol. There are some studies which are proving this. For example, in the same study that was mentioned earlier were a group of elderly men were given 50 mg and 100 mg daily for 12 weeks have proven that they got pretty insignificant increases in the LDL cholesterol (bad cholesterol), however it has come along with a very significant (quite dramatically) suppression in the HDL (good) cholesterol. It showed a reductase of 19 points in the group who were using 50 mg and 23 points in the group who were using 100 mg. This is the why, the use of Oxymetholone needs to be undertaken only after the individual has a very careful consideration of the high cholesterol or a familial history of heart disease. This steroid shouldn’t be used by those people who are already having cholesterol or heart diseases or are prone to getting them.
Remember that it is imperative to have a cholesterol friendly lifestyle as this can greatly help to reduce the potential cardiovascular/ cholesterol issues. In order to reduce the cardiovascular strain, it is strongly advised to keep an active cardiovascular exercise program. Plus to this, a diet would be very important as well. The individual should have a diet where the intake of the saturated fats, simple sugars/ carbohydrates and cholesterol should be minimized or completely avoided in case it is possible. In addition to that, a cholesterol friendly diet should include lots of omega fatty acids, therefore supplementing with daily fish oils (at least 4 grams a day) is greatly recommended.
One last thing - adding a natural cholesterol/ antioxidant formula like for example Lipid Stabil or a product that is having some comparable ingredients is very recommended as well. All of these steps should be maintained during the entire active administration with Oxymetholone.
Oxymetholone Testosterone Suppression Side Effect
Exactly as with absolutely all other anabolic steroids out there, Oxymetholone is going to suppress the natural testosterone production in all men who are using it. The suppression is occurring at different rates depending on the personal response to the drug, on the dosage and so on and so forth. but all the steroids would suppress endogenous testosterone production when used in doses that are sufficient to offer muscle gain. It is important to note that the prolonged hypogonadotrophic hypogonadism can develop if abusing the steroid and this would require medical intervention.
The testosterone is going to be suppressed by taking even low doses of Oxymetholone and this is the main reason why every men is going to need some form of exogenous testosterone if they are using Oxymetholone because their testosterone is nearly surely going to get too suppressed. Those people who do not supplement with some form of exogenous testosterone are having quite a high chance to get into the low testosterone condition which is coming with all the possible symptoms. Generally, low testosterone condition can be very unhealthy for a male and it should be avoided at all costs. It doesn’t matter what exogenous testosterone is added – it can be testosterone cypionate, testosterone enanthate or testosterone propionate, in the end, what really matters is that the user is adding some testosterone in order to avoid low testosterone condition.
As soon as the use of the Oxymetholone (and any other steroid) is going to come to an end, and then all of the anabolic steroids are going to get fully flushed out from the body, the natural testosterone production is going to start once again. However, the pre use levels won’t return back overnight, it is requiring at least a few months, but sometimes it can be even up to a full year. This is the main reason why most men are going to need to introduce a Post Cycle Therapy (PCT) plan in order to help with the recovery. In fact, this practice is recommended to anyone who used steroids as it greatly helps.
Remember that when you are discontinuing with Oxymetholone, the crash can be pretty much exactly as powerful as the oncycle results. like for example, the level of water retention is going to drop down pretty fast, therefore the body weight of the individual would drop pretty fast and quite a lot. But the worst is still going to be the endogenous testosterone production so it is a concern for most people. This is why, before going off this powerful steroid, some people decide to firstly switch over to a milder injectable like for example Deca Durabolin for several weeks before dropping drown all steroids completely. Nonetheless, remember that Deca Durabolin won’t restore testosterone production.
How To Take Anadrol? Anadrol Cycle / Dosage
Oxymetholone Administration Generally
There are studies done in which is suggesting that using an oral anabolic steroid with food may decrease its bioavailability and for this reason, is recommended to use any oral anabolic steroid (including Oxymetholone) on an empty stomach in order to get the maximum out of it. This is being caused by the fat soluble nature of the steroid hormone and this can allow some of the drug to be dissolved with the undigested dietary fat, and that’s why it is reducing its absorption from the gastrointestinal tract.
So, once again, for getting the maximum utilization of Oxymetholone or any other oral anabolic steroid, all of them should be taken on an empty stomach.
Oxymetholone Administration For Men
There are early prescribing guidelines for Oxymetholone and they are suggesting a dosage of 2.5 mg 3 times per day (which means a total of 7.5 mg daily) in order to reverse the wasting process and provide lean body mass gain. Nonetheless, there are still some situations in which doses as high as 30 mg were used.
But the current prescribing guidelines of Oxymetholone is suggesting a dosage anywhere between 1 to 5 mg per kg of bodyweight per day in order to treat anemia condition, even though indicate that a dosage of 1-2 mg/ kg it is usually being considered just enough. With this being said, a 175 pound person would use an approximate dose of 150 mg per day at the 2 mg/ kg dosage level. However, there are some other countries in which the recommended limit of Oxymetholone dose is 100 mg a day. most commonly, the therapy is given for a minimum of 3 months, but it can be up to 6 months.
However, when this steroid is being taken for physique or performance enhancing reasons, is considered that the effective oral dosage should be anywhere in the range of 25 to 150 mg and that’s while it is being taken in cycles that is lasting no more than 6 to 8 weeks in order to minimize the hepatotoxic effect, although there are situations in which is being used for less than that. That level is considered to be enough in order to offer to their users some dramatic increases in their muscle mass and strength and in the same time it is safe enough.
Higher doses are potentially going to enhance the effects making the individual receive more mass and strength, however they are still very rarely administered because of the strong estrogenic nature of the drug which can offer very strong estrogenic side effects but in addition to that, there’s the very high potential for hepatotoxicity. Generally, the side effects risks are getting higher – plus the side effects themselves are getting worse. And it is not sure that doses higher than 150 mg are actually more helpful.
Oxymetholone Administration For Women
The prescribing information for Oxymetholone in the U.S. is making no distinction with the dose for females and with this being said, Oxymetholone is not being recommended for women’s use. That’s because of its extremely strong nature and tendency to produce virilizing side effects, Oxymetholone is not recommended for women for physique and/ or performance enhancing purposes.
The drug should be discontinued at the onset of the side effects but a woman has a high chance to see the first side effect as soon as using the drug. There are other alternatives for women which are considered to be much safer than Oxymetholone.
Where To Buy Anadrol (oxymetholone)?
Why Buy Oxymetholone
Oxymetholone is an oral anabolic steroid that is considered to be very potent, one of the most potent oral steroids available on the market which has derived from dihydrotestosterone. There are athletes that are purchasing Oxymetholone because they deeply appreciate the improvements in their athletic performance and endurance that they are getting from using it and also because it was noticed by many people that this steroid is doing a very good job in improving the joints and the ligaments.
Although it does have some side effects, they can be well controlled. The steroid is only becoming dangerous when is improperly used. As anything in this life – it gets dangerous when abused. By properly using Oxymetholone, a bodybuilder/ athlete is going to appreciate the effects that it can offer during the bulking phase.